A1 - Genetic and Neurobehavioral Predictors of Body Weight and Weight Gain

Brain and behavior are altered in obesity and play an important role in its pathogenesis. Yet the impact of multiple genetic risk factors for obesity on brain structure and function is far from understood. Some of these 'obesity genes' are known to be strongly expressed in the brain, and a first set of studies could relate certain genotypes to structural changes or behavioral phenotypes. However, the relationship between “brain behavior” and obesity is neither unidirectional (“the brain as culprit and victim”), nor mono-causal. Hence, in order to identify specific pathophysiological correlates and underlying mechanisms of a genetic contribution to obesity in human individuals, a complex web of mutual brain–body interactions has to be disentangled. Fig. 1 gives a conceptual framework on the relationship between brain and obesity comprising three different pathophysiological phases

We assess the hypothesis that risk patterns based on multiple genetic variations and neurobehavioral endophenotypes allow for a pathophysiological sub-classification of obesity and prediction of future weight gain. The predictive value of genetic and neurobehavioral information is analysed based on longitudinal studies that assess, besides genotyping, advanced multimodal 3T-neuroimaging, body fat measured using abdominal MRI and impedance analyses, fasting blood markers of leptin, glucose and lipid metabolism, mood, eating behaviour, diet and other lifestyle habits. This will help to identify genetically determined neurobehavioral profiles relevant for obesity, genetic and neurobehavioral determinants for weight prediction, and effects of obesity genes, secondary neurobehavioral and metabolic changes on brain damage. Fig. 2 gives an example of visceral obesity-associated brain atrophy.

Figure 1. Three phases of body-brain interaction in obesity. Genetic and environmental factors lead to a higher risk to develop obesity (left-hand panel). Secondary neurobehavioural and metabolic changes (e.g. inclusing reward areas and leptin resistance) lead to an "addiction-like" phenotype of obesity (middle panel). Late-life consequences of obesity are thought to affect brain structure and function, thereby leading to neurodegeneration and vascular damage (right-hand panel).

 

Figure 2. Lower individual loading on a structural "Alzheimer-related" gray matter network (outlined in A) is associated with higher age, poorer memory performance (B) as well as higher waist-to-hip ratio (C). Bonferroni-corrected partial correlation adjusted for age, sex, and other obestiy-related conditions, n = 616.

Satizabal C., [...], Witte AV, [...], Villringer A, [...], Seshadri S., Genetic Architecture of Subcortical Brain Structures in 38,851 Individuals., Nat Genet. 2019 Oct 21. Epub ahead of print


Medawar E, Huhn S, Villringer A, Witte A., The effects of plant-based diets on the body and the brain: a systematic Review., Transl Psychiatry. 2019 Sep 12;9(1):226.


Beyer F, Kharabian Masouleh S, Kratzsch J, Schroeter ML, Röhr S, Riedel-Heller SG, Villringer A, Witte AV. A Metabolic Obesity Profile Is Associated With Decreased Gray Matter Volume in Cognitively Healthy Older Adults. Front Aging Neurosci. 2019 Aug 2;11:202.


Zsido RG, Heinrich M, Slavich GM, Beyer F, Kharabian Masouleh S, Kratzsch J, Raschpichler M, Mueller K, Scharrer U, Löffler M, Schroeter ML, Stumvoll M, Villringer A, Witte AV, Sacher J. Association of Estradiol and Visceral Fat With Structural Brain Networks and Memory Performance in Adults. JAMA Netw Open. 2019 Jun 5;2(6):e196126.


van den Heuvel MP, Scholtens LH, van der Burgh HK, Agosta F, Alloza C, Arango C, Auyeung B, Baron-Cohen S, Basaia S, Benders MJNL, Beyer F, Booij L, Braun KPJ, Filho GB, Cahn W, Cannon DM, Chaim-Avancini TM, Chan SSM, Chen EYH, Crespo-Facorro B, Crone EA, Dannlowski U, de Zwarte SMC, Dietsche B, Donohoe G, Plessis SD, Durston S, Díaz-Caneja CM, Díaz-Zuluaga AM, Emsley R, Filippi M, Frodl T, Gorges M, Graff B, Grotegerd D, Gąsecki D, Hall JM, Holleran L, Holt R, Hopman HJ, Jansen A, Janssen J, Jodzio K, Jäncke L, Kaleda VG, Kassubek J, Masouleh SK, Kircher T, Koevoets MGJC, Kostic VS, Krug A, Lawrie SM, Lebedeva IS, Lee EHM, Lett TA, Lewis SJG, Liem F, Lombardo MV, Lopez-Jaramillo C, Margulies DS, Markett S, Marques P, Martínez-Zalacaín I, McDonald C, McIntosh AM, McPhilemy G, Meinert SL, Menchón JM, Montag C, Moreira PS, Morgado P, Mothersill DO, Mérillat S, Müller HP, Nabulsi L, Najt P, Narkiewicz K, Naumczyk P, Oranje B, Ortiz-Garcia de la Foz V, Peper JS, Pineda JA, Rasser PE, Redlich R, Repple J, Reuter M, Rosa PGP, Ruigrok ANV, Sabisz A, Schall U, Seedat S, Serpa MH, Skouras S, Soriano-Mas C, Sousa N, Szurowska E, Tomyshev AS, Tordesillas-Gutierrez D, Valk SL, van den Berg LH, van Erp TGM, van Haren NEM, van Leeuwen JMC, Villringer A, Vinkers CH, Vollmar C, Waller L, Walter H, Whalley HC, Witkowska M, Witte AV, Zanetti MV, Zhang R, de Lange SC. 10Kin1day: A Bottom-Up Neuroimaging Initiative. Front Neurol. 2019 May 9;10:425.


Warrington NM, Beaumont RN, Horikoshi M, Day FR, Helgeland Ø, Laurin C, Bacelis J, Peng S, Hao K, Feenstra B, Wood AR, Mahajan A, Tyrrell J, Robertson
NR, Rayner NW, Qiao Z, Moen GH, Vaudel M, Marsit CJ, Chen J, Nodzenski M, Schnurr TM, Zafarmand MH, Bradfield JP, Grarup N, Kooijman MN, Li-Gao R, Geller F, Ahluwalia TS, Paternoster L, Rueedi R, Huikari V, Hottenga JJ, Lyytikäinen LP, Cavadino A, Metrustry S, Cousminer DL, Wu Y, Thiering E, Wang CA, Have CT, Vilor-Tejedor N, Joshi PK, Painter JN, Ntalla I, Myhre R, Pitkänen N, van Leeuwen EM, Joro R, Lagou V, Richmond RC, Espinosa A, Barton SJ, Inskip HM, Holloway JW, Santa-Marina L, Estivill X, Ang W, Marsh JA, Reichetzeder C, Marullo L, Hocher B, Lunetta KL, Murabito JM, Relton CL, Kogevinas M, Chatzi L, Allard C, Bouchard L, Hivert MF, Zhang G, Muglia LJ, Heikkinen J; EGG Consortium, Morgen CS, van Kampen AHC, van Schaik BDC, Mentch FD, Langenberg C, Luan J, Scott RA, Zhao JH, Hemani G, Ring SM, Bennett AJ, Gaulton KJ, Fernandez-Tajes J, van Zuydam NR, Medina-Gomez C, de Haan HG, Rosendaal FR, Kutalik Z, Marques-Vidal P, Das S, Willemsen G, Mbarek H, Müller-Nurasyid M, Standl M, Appel EVR, Fonvig CE, Trier C, van Beijsterveldt CEM, Murcia M, Bustamante M, Bonas-Guarch S, Hougaard DM, Mercader JM, Linneberg A, Schraut KE, Lind PA, Medland SE, Shields BM, Knight BA, Chai JF, Panoutsopoulou K, Bartels M, Sánchez F, Stokholm J, Torrents D, Vinding RK, Willems SM, Atalay M, Chawes BL, Kovacs P, Prokopenko I, Tuke MA, Yaghootkar H, Ruth KS, Jones SE, Loh PR, Murray A, Weedon MN, Tönjes A, Stumvoll M, Michaelsen KF, Eloranta AM, Lakka TA, van Duijn CM, Kiess W, Körner A, Niinikoski H, Pahkala K, Raitakari OT, Jacobsson B, Zeggini E, Dedoussis GV, Teo YY, Saw SM, Montgomery GW, Campbell H, Wilson JF, Vrijkotte TGM, Vrijheid M, de Geus EJCN, Hayes MG, Kadarmideen HN, Holm JC, Beilin LJ, Pennell CE, Heinrich J, Adair LS, Borja JB, Mohlke KL, Eriksson JG, Widén EE, Hattersley AT, Spector TD, Kähönen M, Viikari JS, Lehtimäki T, Boomsma DI, Sebert S, Vollenweider P, Sørensen TIA, Bisgaard H, Bønnelykke K, Murray JC, Melbye M, Nohr EA, Mook-Kanamori DO, Rivadeneira F, Hofman A, Felix JF, Jaddoe VWV, Hansen T, Pisinger C, Vaag AA, Pedersen O, Uitterlinden AG, Järvelin MR, Power C, Hyppönen E, Scholtens DM, Lowe WL Jr, Davey Smith G, Timpson NJ, Morris AP, Wareham NJ, Hakonarson H, Grant SFA, Frayling TM, Lawlor DA, Njølstad PR, Johansson S, Ong KK, McCarthy MI, Perry JRB, Evans DM, Freathy RM. Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors. Nat Genet. 2019 May;51(5):804-814.


Rohde K, Keller M, la Cour Poulsen L, Rønningen T, Stumvoll M, Tönjes A, Kovacs P, Horstmann A, Villringer A, Blüher M, Böttcher Y. (Epi)genetic regulation of CRTC1 in human eating behaviour and fat Distribution. EBioMedicine. 2019 May 29. pii: S2352-3964(19)30358-5.


Beyer F, García-García I, Heinrich M, Schroeter ML, Sacher J, Luck T, Riedel-Heller SG, Stumvoll M, Villringer A, Witte AV. Neuroanatomical correlates of food addiction symptoms and body mass index in the general population. Hum Brain Mapp. 2019 Feb 28.


Lampe L, Zhang R, Beyer F, Huhn S, Kharabian Masouleh S, Preusser S, Bazin PL, Schroeter ML, Villringer A, Witte AV. Visceral obesity relates to deep white matter hyperintensities via inflammation. Ann Neurol. 2019 Feb;85(2):194-203.


Vojinovic D, Adams HH, Jian X, Yang Q, Smith AV, Bis JC, Teumer A, Scholz M, Armstrong NJ, Hofer E, Saba Y, Luciano M, Bernard M, Trompet S, Yang J, Gillespie NA, van der Lee SJ, Neumann A, Ahmad S, Andreassen OA, Ames D, Amin N, Arfanakis K, Bastin ME, Becker DM, Beiser AS, Beyer F, Brodaty H, Bryan RN, Bülow R, Dale AM, De Jager PL, Deary IJ, DeCarli C, Fleischman DA, Gottesman RF, van der Grond J, Gudnason V, Harris TB, Homuth G, Knopman DS, Kwok JB, Lewis CE, Li S, Loeffler M, Lopez OL, Maillard P, El Marroun H, Mather KA, Mosley TH, Muetzel RL, Nauck M, Nyquist PA, Panizzon MS, Pausova Z, Psaty BM, Rice K, Rotter JI, Royle N, Satizabal CL, Schmidt R, Schofield PR, Schreiner PJ, Sidney S, Stott DJ, Thalamuthu A, Uitterlinden AG, Valdés Hernández MC, Vernooij MW, Wen W, White T, Witte AV, Wittfeld K, Wright MJ, Yanek LR, Tiemeier H, Kremen WS, Bennett DA, Jukema JW, Paus T, Wardlaw JM, Schmidt H, Sachdev PS, Villringer A, Grabe HJ, Longstreth WT, van Duijn CM, Launer LJ, Seshadri S, Ikram MA, Fornage M. Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume.Nat Commun. 2018 Nov 23;9(1):4960.


Püschel J, Miehle K, Müller K, Villringer AStumvoll MFasshauer M, Schlögl H. Beneficial effects of leptin substitution on impaired eating behavior in lipodystrophy are sustained beyond 150 weeks of treatment. Cytokine. 2019 Jan;113:400-404.


Hardikar S, Wallroth R, Villringer A, Ohla K. Shorter-lived neural taste representations in obese compared to lean individuals. Sci Rep. 2018 Jul 23;8(1):11027.


Huhn S, Beyer F, Zhang R, Lampe L, Grothe J, Kratzsch J, Willenberg A, Breitfeld J, Kovacs PStumvoll M, Trampel R, Bazin PL, Villringer AWitte AV. Effects of resveratrol on glucose, memory and the hippocampus - a randomized controlled trial. Neuroimage. 2018 Mar 13;174:177-190.


Zhang R, Beyer F, Lampe L, Luck T, Riedel-Heller SG, Loeffler M, Schroeter ML, Stumvoll MVillringer A, Witte AV. White matter microstructural variability mediates the relation between obesity and cognition in healthy adults.Neuroimage. 2018 Feb 2;172:239-249


Schwarz C, Wirth M, Gerischer L, Grittner U, Witte AV, Köbe T, Flöel A. Effects of Omega-3 Fatty Acids on Resting Cerebral Perfusion in Patients with Mild Cognitive Impairment: A Randomized Controlled Trial. J Prev Alzheimers Dis. 2018;5(1):26-30.


Hellrung L, Dietrich A, Hollmann M, Pleger B, Kalberlah C, Roggenhofer E, Villringer A, Horstmann A. Intermittent compared to continuous real-time fMRI neurofeedback boosts control over amygdala activation. NeuroImage. 2017;166:198-208.


Rodriguez FS, Schroeter ML, Arélin K, Witte AV, Baber R, Burkhardt R, Engel C, Löffler M, Thiery J, Villringer A, Luck T, Riedel-Heller SG. APOE e4-genotype and lifestyle interaction on cognitive performance: Results of the LIFE-Adult-study.Health Psychol. 2018 Feb;37(2):194-205.


Tönjes A, Scholz M, Krüger J, Krause K, Schleinitz D, Kirsten H, Gebhardt C, Marzi C, Grallert H, Ladenvall C, Heyne H, Laurila E, Kriebel J, Meisinger C, Rathmann W, Gieger C, Groop L, Prokopenko I, Isomaa B, Beutner F, Kratzsch J, Fischer-Rosinsky A, Pfeiffer A, Krohn K, Spranger J, Thiery J, Blüher M, Stumvoll M, Kovacs P. Genome wide meta-analysis identifies novel determinants of circulating serum progranulin. Hum Mol Genet. 2018 Feb 1;27(3):546-558.


Huhn S, Beyer F, Zhang R, Lampe L, Grothe J, Kratzsch J, Willenberg A, Breitfeld J, Kovacs P, Stumvoll M, Trampel R, Bazin PL, Villringer A, Witte AV. Effects of resveratrol on memory performance, hippocampus connectivity and microstructure in older adults - A randomized controlled trial. Neuroimage. 2018 Mar 13;174:177-190.


Ebert T, Gebhardt C, Scholz M, Wohland T, Schleinitz D, Fasshauer M, Blüher M, Stumvoll M, Kovacs P, Tönjes A. Relationship between twelve adipocytokines and distinct components of the metabolic syndrome. JClinEndocrinol Metab. 2018: 10.1210/jc.2017-02085 


Gepner Y, Shelef I, Schwarzfuchs D, Cohen N, Bril N, Rein M, Tsaban G, Zelicha H, Yaskolka Meir A, Tene L, Sarusy B, Rosen P, Hoffman JR, Stout JR, Thiery J, Ceglarek U, Stumvoll M, Blüher M, Stampfer MJ, Shai I. Intramyocellular triacylglycerol accumulation across weight loss strategies; Sub-study of the CENTRAL trial. PLoS One. 2017;12:e0188431.


Gepner Y, Shelef I, Schwarzfuchs D, Zelicha H, Tene L, Yaskolka Meir A, Tsaban G, Cohen N, Bril N, Rein M, Serfaty D, Kenigsbuch S, Komy O, Wolak A, Chassidim Y, Golan R, Avni-Hassid H, Bilitzky A, Sarusi B, Goshen E, Shemesh E, Henkin Y, Stumvoll M, Blüher M, Thiery J, Ceglarek U, Rudich A, Stampfer MJ, Shai I. Effect of distinct lifestyle interventions on mobilization of fast storage pools: the CENTRAL MRI randomized control trial. Circulation. 2017; Epub ahead of print.


Kastner L, Kube J, Villringer A, Neumann J. Cardiac concomitants of feedback and prediction error processing in reinforcement learning. Front Neurosci. 2017;11:598.


Hellrung L, Dietrich A, Hollmann M, Pleger B, Kalberlah C, Roggenhofer E, Villringer A, Horstmann A. Intermittent compared to continuous real-time fMRI neurofeedbak boosts control over amygdala activation. NeuroImage. 2017;166:198-208.


Kharabian Masouleh S, Beyer F, Lampe L, Loeffler M, Luck T, Riedel-Heller SG, Schroeter ML, Stumvoll MVillringer A, Witte AV. Gray matter structural networks are associated with cardiovascular risk factors in healthy older adults. J Cereb Blood Flow Metab. 2017; Epub ahead of print.


Mathar D, Neumann J, Villringer A, Horstmann A. Failing to learn from negative prediction errors: Obesity is associated with alterations in a fundamental neural learning mechanism. Cortex. 2017;95:222-37.


Rohde K, Klös M, Hopp L, Liu X, Keller M, Stumvoll M, Dietrich A, Schön MR, Gärtner D, Lohmann T, Dreßler M, Kovacs P, Binder H, Blüher M, Böttcher Y. IRS1 DNA promoter methylation and expression in human adipose tissue are related to fat distribution and metabolic traits. Sci Rep. 2017;7:12369.


Tsaban G, Wolak A, Avni-Hassid H, Gepner Y, Shelef I, Henkin Y, Schwarzfuchs D, Cohen N, Bril N, Rein M, Serfaty D, Kenigsbuch S, Tene L, Zelicha H, Yaskolka-Meir A, Komy O, Bilitzky A, Chassidim Y, Ceglarek U, Stumvoll M, Blüher M, Thiery J, Dicker D, Rudich A, Stamper MJ, Shai I. Dynamics of intrapericardial and extrapericardial fat tissues during long-term, dietary-induced, moderate weight loss. Am J Clin Nutr. 2017;106:984-95.


Kralisch S, Hoffmann A, Kratzsch J, Blüher M, Stumvoll M, Fasshauer M, Ebert T. The brown-fat-secreted adipokine neuregulin 4 is decreased in gestational diabetes mellitus. Diabetes Metab. 2017; Epub ahead of print.


Rodriguez FS, Schroeter ML, Witte AV, Engel C, Löffler M, Thiery J, Villringer A, Luck T, Riedel-Heller SG. Could high mental demands at work offset the adverse association between social isolation and cognitive functioning? Results of population-based LIFE-adult-study. Am J Geriatr Psychiatry. 2017;25:1258-69.


Polyakova M, Schlögl H, Sacher J, Schmidt-Kassow M, Kaiser J, Stumvoll M, Kratzsch J, Schroeter ML. Stability of BDNF in human samples stored up to 6 months and correlations of serum and EDTA-plasma concentrations. Int J Mol Sci. 2017;18:1189.


Weiner J, Rohde K, Krause K, Zieger K, Klöting N, Kralisch S, Kovacs P, Stumvoll M, Blüher M, Böttcher Y, Heiker JT. Brown adipose tissue (BAT) specific vaspin expression is increased after obesogenic diets and cold exposure and linked to acute changes in DNA-methylation. Mol Met. 2017; Epub ahead of print.


Keller M, Hopp L, Liu X, Wohland T, Rohde K, Cancello R, Klös M, Bacos K, Kern M, Eichelmann F, Dietrich A, Schön MR, Gärtner D, Lohmann T, Dreßler M, Stumvoll M, Kovacs P, DiBlasio AM, Ling C, Binder H, Blüher M, Böttcher Y. Genome-wide DNA promoter methylation and transcriptome analysis in human adipose tissue unravels novel candidate genes for obesity. Mol Metab. 2016;6:86-100.


Hardikar S, Höchenberger R, Villringer A, Ohla K. Higher sensitivity to sweet and salty taste in obese compared to lean individuals. Appetite. 2017;111:158-65.


Schrimpf A, Kube J, Neumann J, Horstmann A, Villringer A, Gaebler M. Parasympathetic cardio-regulation during social interactions in individuals with obesity - The influence of negative body image. Cogn Affect Behav Neurosci. 2017;17:330-47.


Horikoshi M, Beaumont RN, Day FR, Warrington NM, Kooijman MN, Fernandez-Tajes J, Feenstra B, van Zuydam NR, Gaulton KJ, Grarup N, Bradfield JP, Strachan DP, Li-Gao R, Ahluwalia TS, Kreiner E, Rueedi R, Lyytikäinen LP, Cousminer DL, Wu Y, Thiering E, Wang CA, Have CT, Hottenga JJ, Vilor-Tejedor N, Joshi PK, Boh ET, Ntalla I, Pitkänen N, Mahajan A, van Leeuwen EM, Joro R, Lagou V, Nodzenski M, Diver LA, Zondervan KT, Bustamante M, Marques-Vidal P, Mercader JM, Bennett AJ, Rahmioglu N, Nyholt DR, Ma RC, Tam CH, Tam WH; CHARGE Consortium Hematology Working Group, Ganesh SK, van Rooij FJ, Jones SE, Loh PR, Ruth KS, Tuke MA, Tyrrell J, Wood AR, Yaghootkar H, Scholtens DM, Paternoster L, Prokopenko I, Kovacs P, Atalay M, Willems SM, Panoutsopoulou K, Wang X, Carstensen L, Geller F, Schraut KE, Murcia M, van Beijsterveldt CE, Willemsen G, Appel EV, Fonvig CE, Trier C, Tiesler CM, Standl M, Kutalik Z, Bonàs-Guarch S, Hougaard DM, Sánchez F, Torrents D, Waage J, Hollegaard MV, de Haan HG, Rosendaal FR, Medina-Gomez C, Ring SM, Hemani G, McMahon G, Robertson NR, Groves CJ, Langenberg C, Luan J, Scott RA, Zhao JH, Mentch FD, MacKenzie SM, Reynolds RM; Early Growth Genetics (EGG) Consortium, Lowe WL, Tönjes A, Stumvoll M, Lindi V, Lakka TA, van Duijn CM, Kiess W, Körner A, Sørensen TI, Niinikoski H, Pahkala K, Raitakari OT, Zeggini E, Dedoussis GV, Teo YY, Saw SM, Melbye M, Campbell H, Wilson JF, Vrijheid M, de Geus EJ, Boomsma DI, Kadarmideen HN, Holm JC, Hansen T, Sebert S, Hattersley AT, Beilin LJ, Newnham JP, Pennell CE, Heinrich J, Adair LS, Borja JB, Mohlke KL, Eriksson JG, Widén E, Kähönen M, Viikari JS, Lehtimäki T, Vollenweider P, Bønnelykke K, Bisgaard H, Mook-Kanamori DO, Hofman A, Rivadeneira F, Uitterlinden AG, Pisinger C, Pedersen O, Power C, Hyppönen E, Wareham NJ, Hakonarson H, Davies E, Walker BR, Jaddoe VW, Järvelin MR, Grant SF, Vaag AA, Lawlor DA, Frayling TM, Smith GD, Morris AP, Ong KK, Felix JF, Timpson NJ, Perry JR, Evans DM, McCarthy MI, Freathy RM. Genome-wide associations for birth weight and correlations with adult disease. Nature. 2016;538:248-52.


Guiu-Jurado E, Unthan M, Böhler N, Kern M, Landgraf K, Dietrich A, Schleinitz D, Ruschke K, Klöting N, Faßhauer M, Tönjes A, Stumvoll M, Körner A, Kovacs P, Blüher M. Bone morphogenetic protein 2 (BMP2) may contribute to partition of energy storage into visceral and subcutaneous fat depots. Obesity (Silver Spring). 2016;24:2092-100.


Garcia-Garcia I, Kube J, Gaebler M, Horstmann A, Villringer A, Neumann J. Neural processing of negative emotional stimuli and the influence of age, sex and task-related characteristics. Neurosci Biobehav Rev. 2016;68:773-93.


Grellmann C, Neumann J, Bitzer S,Kovacs P,Tönjes A, Westlye LT, Anreassen OA, Stumvoll MVillringer A, Horstmann A. Random projection for fast and efficient multivariate correlation analysis of high-dimensional data: A new approach. Front Genet. 2016;7:102.


Kharabian Masouleh S, Arelin K, Horstmann A, Lample L, Kipping JA, Luck T, Riedel-Heller SG, Schroeter ML, Stumvoll MVillringer A, Witte AV. Higher body mass index in older adults is associated with lower gray matter volume: implications for memory performance. Neurobiol Aging. 2016;40:1-10.


Köbe T, Witte AV, Schnelle A, Grittner U, Tesky VA, Pantel J, Schuchardt JP, Hahn A, Bohlken J, Rujescu D, Flöel A. Vitamin B-12 concentration, memory performance, and hippocampal structure in patients with mild cognitive impairment. Am J Clin Nutr. 2016;103:1045-54.


Köbe T, Witte AV, Schnelle A, Lesemann A, Fabian S, Tesky VA, Pantel J, Flöel A. Combined omega-3 fatty acids, aerobic exercise and cognitive stimulation prevents decline in gray matter volume of the frontal, parietal and cingulate cortex in patients with mild cognitive impairment. Neuroimage. 2016;131:226-38.


Schlögl H, Horstmann A, Villringer AStumvoll M. Functional neuroimaging in obesity and the potential for development of novel treatments. Lancet Diabetes Endocrinol. 2016;4:695-705.


Huhn S, Kharabian Masouleh S, Stumvoll MVillringer A, Witte V. Components of a Mediterranean diet and their impact on cognitive funtions in aging. Front Aging Neurosci. 2015;7:132.


Mueller K, Möller HE, Horstmann A, Busse-Voigt FP, Lepsien J, Blüher M, Stumvoll MVillringer A, Pleger B. Physical exercise in overweight to obese individuals induces metabolic- and neurotrophic-related structural brain plasticity. Front Hum Neurosci. 2015;9:372.


Rohde K, Federbusch M, Horstmann A, Keller M, Villringer AStumvoll M, Tönjes A, Kovacs P, Böttcher Y. Genetic variants in AKR1B10 associate with human eating behavior. BMC Genet. 2015;16:31.


Hellrung L, Hollmann M, Zscheyge O, Schlumm T, Kalberlah C, Roggenhofer E, Okon-Singer H, Villringer A, Horstmann A. Flexible adaptive paradigms for fMRI using a novel software package 'Brain Analysis in Real-Time' (BART). PLoS One. 2015;10:e0118890.


Horstmann A, Kovacs P, Kabisch S, Boettcher Y, Schloegl H, Toenjes A, Stumvoll M, Pleger B, Villringer A. Common genetic variation near MC4R has a sex-specific impact on human brain structure and brain behavior. PLoS One. 2013;8:e74362.


Schroeter ML, Vogt B, Frisch S, Becker G, Barthel H, Mueller K, Villringer A, Sabri O. Executive deficits are related to the inferior frontal junction in early dementia. Brain. 2012;135:201-15.


Horstmann A, Busse FP, Mathar D, Müller K, Lepsien J, Schlögl H, Kabisch S, Kratzsch J, Neumann J, Stumvoll MVillringer A, Pleger B. Obesity-related differences between women and men in brain structure and goal-directed behavior. Front Hum Neurosci. 2011;5:58.


Hollmann M, Hellrung L, Pleger B, Schlögl H, Kabisch S, Stumvoll MVillringer A, Horstmann A. Neural correlates of the volitional regulation of the desire for  food. Int J Obes (Lond). 2011;36:648-55.


Mueller K, Anwander A, Möller HE, Horstmann A, Lepsien J, Busse F, Mohammadi S, Schroeter ML, Stumvoll MVillringer A, Pleger B. Sex-dependent influences of obesity on cerebral white matter investigated by diffusion-tensor imaging. PLoS One. 2011;6:e18544.


Tönjes A, Zeggini E, Kovacs P, Böttcher Y, Schleinitz D, Dietrich K, Morris AP, Enigk B, Rayner NW, Koriath M, Eszlinger M, Kemppinen A, Prokopenko I, Hoffmann K, Teupser D, Thiery J, Krohn K, McCarthy MI, Stumvoll M. Association of FTO variants with BMI and fat mass in the self-contained population of Sorbs in Germany. Eur J Hum Genet. 2010;18:104-10.


Saxena R, Hivert MF, Langenberg C, Tanaka T, [69 authors], Kovacs P, [29 authors], Tönjes A, [34 authors], Stumvoll M, [16 authors], Watanabe RM. Genetic variation in gastric inhibitory polypeptide receptor (GIPR) impacts the glucose and insulin responses to an oral glucose challenge. Nat Genet. 2010;42:142-8.


Speliotes EK, Willer CJ, Berndt SI, Monda KL, [167 authors], Kovacs P, [80 authors], Tönjes A, [35 authors], Stumvoll M, [87 authors], Loos RJ. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet. 2010;42:937-48.


Taubert M, Draganski B, Anwander A, Müller K, Horstmann A, Villringer A, Ragert P. Dynamic properties of human brain structure: learning-related changes in cortical areas and associated fiber connections. J Neurosci. 2010;30:11670-7.


Ritter P, Moosmann M, Villringer A. Rolandic alpha and beta EEG rhythms' strengths are inversely related to fMRI-BOLD signal in primary somatosensory and motor cortex. Hum Brain Mapp. 2009;30:1168-87.


Führer D, Zysset S, Stumvoll M. Brain activity in hunger and satiety: an exploratory visually stimulated FMRI study. Obesity (Silver Spring). 2008;16:945-50.


Marschner A, Mell T, Wartenburger I, Villringer A, Reischies FM, Heekeren HR. Reward-based decision-making and aging. Brain Res Bull. 2005;67:382-90.


Blankenburg F, Taskin B, Ruben J, Moosmann M, Ritter P, Curio G, Villringer A. Imperceptible stimuli and sensory processing impediment. Science. 2003;299:1864.

PROJECT TEAM

Dr. Veronica Witte, Young research group leader

Frauke Beyer, PhD student

Rui Zhang, PhD student

Ronja Thieleking, PhD student