Z6 - Identification of molecular mechanisms and druggable targets for the treatment of obesity
Project Z6 supports the CRC in providing computational and experimental information on the structure and function of the studied proteins in particular concerning (i) understanding of the molecular basis of protein function and malfunction, (ii) structure-based drug development, and (iii) characterizing disease-causing mechanisms of protein mutations associated with obesity. Specifically, we will use structural biology approaches such as X-ray crystallography or computation. The objective of this new core project is to establish an iterative loop of computational modeling, structural biology, and biochemical characterization to determine the functional mechanism of genetic variations. Ultimately, these studies can contribute to the development of effective treatment strategies.